Knowing your triggers is essential to staying safe from severe angioedema, a potentially life-threatening allergic reaction. Common causes include food allergens, insect stings, and medications. One important trigger to be aware of is ceftriaxone injection, a widely used antibiotic. In some individuals, ceftriaxone can provoke serious allergic reactions, including angioedema. Always inform your healthcare provider of any allergies before receiving medications. If you’ve previously reacted to antibiotics or have a history of angioedema, request an alternative treatment. Being proactive, reading labels, and carrying emergency medication can help you manage your risk and stay safe from severe angioedema episodes.