Obstructive sleep apnea is one of the most common causes of chronic sleep disturbance, and it can lead to daytime fatigue and headaches. Modafinil 200 mg treating this condition can help prevent headaches and enhance wakefulness. Similarly, if you have a chronic headache, you should get a complete medical examination to rule out a neurological problem such as a brain tumor. Acupuncture can also be helpful in reducing headache frequency and severity, as can biofeedback therapy and relaxation training.